Genomic Region Containing Toll-Like Receptor Genes Has a Major Impact on Total IgM Antibodies Including KLH-Binding IgM Natural Antibodies in Chickens

Genomic Region Containing Toll-Like Receptor Genes Has a Major Impact on Total IgM Antibodies Including KLH-Binding IgM Natural Antibodies in Chickens

Natural antibodies (NAb) are antigen binding antibodies present in individuals without a previous exposure to this antigen. Keyhole limpet hemocyanin (KLH)-binding NAb levels were previously associated with survival in chickens. This suggests that selective breeding for KLH-binding NAb may increase...

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Bibliographic Details
Main Authors: Tom V. L. Berghof, Marleen H. P. W. Visker, Joop A. J. Arts, Henk K. Parmentier, Jan J. van der Poel, Addie L. J. Vereijken, Henk Bovenhuis
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
natural antibody
antibody concentration
genetic parameter
heritability
genome-wide association study
B cell development
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01879/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01879/full

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