Enhancement of Mucosal Immunogenicity of Viral Vectored Vaccines by the NKT Cell Agonist Alpha-Galactosylceramide as Adjuvant

Enhancement of Mucosal Immunogenicity of Viral Vectored Vaccines by the NKT Cell Agonist Alpha-Galactosylceramide as Adjuvant

Gene-based vaccination strategies, specifically viral vectors encoding vaccine immunogens are effective at priming strong immune responses. Mucosal routes offer practical advantages for vaccination by ease of needle-free administration, and immunogen delivery at readily accessible oral/nasal sites t...

Full description

Bibliographic Details
Main Authors: Shailbala Singh, Pramod N. Nehete, Guojun Yang, Hong He, Bharti Nehete, Patrick W. Hanley, Michael A. Barry, K. Jagannadha Sastry
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:Vaccines
Subjects:
adenovirus vector
vesicular stomatitis viral vector
intranasal
HIV vaccine
Rhesus macaques
alpha-galactosylceramide
mucosal immunity
NKT cells
Online Access:http://www.mdpi.com/2076-393X/2/4/686

Internet

http://www.mdpi.com/2076-393X/2/4/686

Similar Items