Intranuclear inclusions in hepatocellular carcinoma contain autophagy‐associated proteins and correlate with prolonged survival

Intranuclear inclusions in hepatocellular carcinoma contain autophagy‐associated proteins and correlate with prolonged survival

Abstract For decades, intranuclear inclusions in many normal and neoplastic cells have been considered to be mere invaginations of cytoplasm into the nucleus without any notable function or influence on disease. We investigated such inclusions in 75 specimens of hepatocellular carcinoma (HCC). In th...

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Bibliographic Details
Main Authors: Suzan Schwertheim, Daniela Westerwick, Holger Jastrow, Sarah Theurer, Christoph M Schaefer, Julia Kälsch, Dorothe Möllmann, Martin Schlattjan, Heiner Wedemeyer, Kurt Werner Schmid, Hideo A Baba
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:The Journal of Pathology: Clinical Research
Subjects:
intranuclear inclusions
autophagy
lysosomal proteins
HCC
Online Access:https://doi.org/10.1002/cjp2.129

Internet

https://doi.org/10.1002/cjp2.129

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