NS5-V372A and NS5-H386Y variations are responsible for differences in interferon α/β induction and co-contribute to the replication advantage of Japanese encephalitis virus genotype I over genotype III in ducklings.

Japanese encephalitis virus (JEV) genotype I (GI) replicates more efficiently than genotype III (GIII) in birds, and this difference is considered to be one of the reasons for the JEV genotype shift. In this study, we utilized duck embryo fibroblasts and domestic ducklings as in vitro and in vivo mo...

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Bibliographic Details
Main Authors: Chenxi Li, Di Di, Hui Huang, Xin Wang, Qiqi Xia, Xiaochun Ma, Ke Liu, Beibei Li, Donghua Shao, Yafeng Qiu, Zongjie Li, Jianchao Wei, Zhiyong Ma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008773