Slow Ca2+ Efflux by Ca2+/H+ Exchange in Cardiac Mitochondria Is Modulated by Ca2+ Re-uptake via MCU, Extra-Mitochondrial pH, and H+ Pumping by FOF1-ATPase

Slow Ca2+ Efflux by Ca2+/H+ Exchange in Cardiac Mitochondria Is Modulated by Ca2+ Re-uptake via MCU, Extra-Mitochondrial pH, and H+ Pumping by FOF1-ATPase

Mitochondrial (m) Ca2+ influx is largely dependent on membrane potential (ΔΨm), whereas mCa2+ efflux occurs primarily via Ca2+ ion exchangers. We probed the kinetics of Ca2+/H+ exchange (CHEm) in guinea pig cardiac muscle mitochondria. We tested if net mCa2+ flux is altered during a matrix inward H+...

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Bibliographic Details
Main Authors: Johan Haumann, Amadou K. S. Camara, Ashish K. Gadicherla, Christopher D. Navarro, Age D. Boelens, Christoph A. Blomeyer, Ranjan K. Dash, Michael R. Boswell, Wai-Meng Kwok, David F. Stowe
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Physiology
Subjects:
cardiac mitochondria
Ca2+ uptake/release
mitochondrial Ca2+ uniporter
Ca2+/H+ exchange
H+ leak and pumping
complex V
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01914/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01914/full

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