The effect of spironolactone on calcineurin inhibitor induced nephrotoxicity: a multicenter randomized, double-blind, clinical trial (the SPIREN trial)

The effect of spironolactone on calcineurin inhibitor induced nephrotoxicity: a multicenter randomized, double-blind, clinical trial (the SPIREN trial)

Abstract Background Calcineurin inhibitor induced nephrotoxicity contributes to late allograft failure in kidney transplant patients. Evidence points towards aldosterone to play a role in the development of fibrosis in multiple organs. Animal studies have indicated a beneficial effect of mineralocor...

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Bibliographic Details
Main Authors: Line Aas Mortensen, Helle C. Thiesson, Birgitte Tougaard, Martin Egfjord, Anne Sophie Lind Fischer, Claus Bistrup
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Nephrology
Subjects:
Aldosterone
Mineralocorticoid
Kidney transplantation
Cyclosporine A
Tacrolimus
IFTA
Online Access:http://link.springer.com/article/10.1186/s12882-018-0885-6

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http://link.springer.com/article/10.1186/s12882-018-0885-6

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