A Facile and Sensitive Method for Quantification of Cyclic Nucleotide Monophosphates in Mammalian Organs: Basal Levels of Eight cNMPs and Identification of 2',3'-cIMP

A Facile and Sensitive Method for Quantification of Cyclic Nucleotide Monophosphates in Mammalian Organs: Basal Levels of Eight cNMPs and Identification of 2',3'-cIMP

A sensitive, versatile and economical method to extract and quantify cyclic nucleotide monophosphates (cNMPs) using LC-MS/MS, including both 3',5'-cNMPs and 2',3'-cNMPs, in mammalian tissues and cellular systems has been developed. Problems, such as matrix effects from complex bi...

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Bibliographic Details
Main Authors: Xin Jia, Benjamin M. Fontaine, Fred Strobel, Emily E. Weinert
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:Biomolecules
Subjects:
liquid chromatography
tandem mass spectrometry
LC-MS/MS
3',5'-cyclic nucleotides monophosphate
2',3'-cyclic nucleotides monophosphate
inosine 2',3'-cyclic monophosphate
mammalian cNMP basal levels
Online Access:http://www.mdpi.com/2218-273X/4/4/1070

Internet

http://www.mdpi.com/2218-273X/4/4/1070

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