Effect of Ginkgo biloba extract combined with prednisone on bronchoalveolar lavage fluid related cytokines in patients with IPF

Effect of Ginkgo biloba extract combined with prednisone on bronchoalveolar lavage fluid related cytokines in patients with IPF

Objective: To explore the effect of Ginkgo biloba extract (EGb) combined with prednisone on bronchoalveolar lavage fluid (BALF) related cytokines in patients with idiopathic pulmonary fibrosis (IPF). Methods: A total of 60 patients with IPF who were admitted in our hospital from March, 2015 to Ma...

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Bibliographic Details
Main Author: Zhen-Chun Shi
Format: Article
Language:English
Published: Editorial Board of Journal of Hainan Medical University 2016-09-01
Series:Journal of Hainan Medical University
Subjects:
EGb
Male
Bachelor Degree
Associate Pharmacist. Tel: 13303131007 E-mail: szc850614884@sina.com Foundation project: The study was supported by the Scientific and Technological Achievement Awards Project of Hebei Province with the number of 20120150. 1. Introduction Idiopathic pulmonary fibrosis (IPF) is a disease characterized by pulmonary interstitial fibrosis caused by alveolar structure disorder
diffused pulmonary alveolitis
and interstitial pneumonia
with manifestations of progressive and aggravated dyspnea
and restrictive ventilatory function
and can cause cardio-pulmonary failure to death in the advanced stage[1]. The pathogenesis of IPF is not yet clear. With a continuously deep study on cellular and molecular biology
it is argued that due to the damage of pathogenic factors on the alveolar epithelial cells
the inflammatory cells and immunologic effector cells enter the alveoli to release a large amount of cytokines and inflammatory mediators
and promote the extracellular matrix deposition
collagen accumulation
and the activation and proliferation of lung fibroblasts
finally Objective: To explore the effect of Ginkgo biloba extract (EGb) combined with prednisone on bronchoalveolar lavage fluid (BALF) related cytokines in patients with idiopathic pulmonary fibrosis (IPF). Methods: A total of 60 patients with IPF who were admitted in our hospital from March
2015 to March
2016 were included in the study and randomized into the observation group and the control group with 30 cases in each group. The patients in the two groups were given oxygen inhalation
bronchodilator agents
phlegm dissipating and asthma relieving
anti-infection
and other supporting treatments. The patients in the control group were orally given prednisone (0.5 mg/kg•d)
continuously for 4 weeks
then in a dose of 0.25 mg/kg•d
continuously for 8 weeks
Prednisone
IPF
BALF
Cytokine
Pulmonary function
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