Tumor cell heterogeneity in Small Cell Lung Cancer (SCLC): phenotypical and functional differences associated with Epithelial-Mesenchymal Transition (EMT) and DNA methylation changes.

Tumor cell heterogeneity in Small Cell Lung Cancer (SCLC): phenotypical and functional differences associated with Epithelial-Mesenchymal Transition (EMT) and DNA methylation changes.

Small Cell Lung Cancer (SCLC) is a specific subtype of lung cancer presenting as highly metastatic disease with extremely poor prognosis. Despite responding initially well to chemo- or radiotherapy, SCLC almost invariably relapses and develops resistance to chemotherapy. This is suspected to be rela...

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Bibliographic Details
Main Authors: Alexander Krohn, Theresa Ahrens, Arzu Yalcin, Till Plönes, Julius Wehrle, Sanaz Taromi, Stefan Wollner, Marie Follo, Thomas Brabletz, Sendurai A Mani, Rainer Claus, Björn Hackanson, Meike Burger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4069054?pdf=render

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http://europepmc.org/articles/PMC4069054?pdf=render

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