HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics

Human immunodeficiency virus (HIV)-1 infection is initiated by the binding of gp120 envelope glyco-protein to its cell receptor (CD4) and a coreceptor (CXCR4 or CCR5), followed by a series of conformational changes in the gp41 transmembrane subunit. These changes include insertion of fusion peptide...

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Bibliographic Details
Main Authors: Chungen Pan, Shuwen Liu, Shibo Jiang
Format: Article
Language:English
Published: Elsevier 2010-02-01
Series:Journal of the Formosan Medical Association
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0929664610600290