Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis

The plasma membrane is enriched in phosphatidylserine (PtdSer) mostly localized at the inner leaflet, which is predicted to induce membrane curvature. Here the authors show that membrane curvature induced by the proximity of anionic phospholipids can induce endocytosis and that cholesterol limits sp...

Full description

Bibliographic Details
Main Authors:	Takashi Hirama, Stella M. Lu, Jason G. Kay, Masashi Maekawa, Michael M. Kozlov, Sergio Grinstein, Gregory D. Fairn
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01554-9

id	doaj-1c22c972acee4860ae917618ded44d94
record_format	Article
spelling	doaj-1c22c972acee4860ae917618ded44d942021-05-11T07:53:32ZengNature Publishing GroupNature Communications2041-17232017-11-018111410.1038/s41467-017-01554-9Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosisTakashi Hirama0Stella M. Lu1Jason G. Kay2Masashi Maekawa3Michael M. Kozlov4Sergio Grinstein5Gregory D. Fairn6Program in Cell Biology, The Hospital for Sick ChildrenProgram in Cell Biology, The Hospital for Sick ChildrenDepartment of Oral Biology, School of Dental Medicine, University at BuffaloKeenan Research Centre for Biomedical Science, St. Michael’s HospitalDepartment of Physiology and Pharmacology, Room 546, Sackler Faculty of Medicine, Tel Aviv UniversityProgram in Cell Biology, The Hospital for Sick ChildrenKeenan Research Centre for Biomedical Science, St. Michael’s HospitalThe plasma membrane is enriched in phosphatidylserine (PtdSer) mostly localized at the inner leaflet, which is predicted to induce membrane curvature. Here the authors show that membrane curvature induced by the proximity of anionic phospholipids can induce endocytosis and that cholesterol limits spontaneous curvature.https://doi.org/10.1038/s41467-017-01554-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Takashi Hirama Stella M. Lu Jason G. Kay Masashi Maekawa Michael M. Kozlov Sergio Grinstein Gregory D. Fairn
spellingShingle	Takashi Hirama Stella M. Lu Jason G. Kay Masashi Maekawa Michael M. Kozlov Sergio Grinstein Gregory D. Fairn Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis Nature Communications
author_facet	Takashi Hirama Stella M. Lu Jason G. Kay Masashi Maekawa Michael M. Kozlov Sergio Grinstein Gregory D. Fairn
author_sort	Takashi Hirama
title	Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis
title_short	Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis
title_full	Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis
title_fullStr	Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis
title_full_unstemmed	Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis
title_sort	membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-11-01
description	The plasma membrane is enriched in phosphatidylserine (PtdSer) mostly localized at the inner leaflet, which is predicted to induce membrane curvature. Here the authors show that membrane curvature induced by the proximity of anionic phospholipids can induce endocytosis and that cholesterol limits spontaneous curvature.
url	https://doi.org/10.1038/s41467-017-01554-9
work_keys_str_mv	AT takashihirama membranecurvatureinducedbyproximityofanionicphospholipidscaninitiateendocytosis AT stellamlu membranecurvatureinducedbyproximityofanionicphospholipidscaninitiateendocytosis AT jasongkay membranecurvatureinducedbyproximityofanionicphospholipidscaninitiateendocytosis AT masashimaekawa membranecurvatureinducedbyproximityofanionicphospholipidscaninitiateendocytosis AT michaelmkozlov membranecurvatureinducedbyproximityofanionicphospholipidscaninitiateendocytosis AT sergiogrinstein membranecurvatureinducedbyproximityofanionicphospholipidscaninitiateendocytosis AT gregorydfairn membranecurvatureinducedbyproximityofanionicphospholipidscaninitiateendocytosis
_version_	1721451361592147968

Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis

Similar Items