Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis

The plasma membrane is enriched in phosphatidylserine (PtdSer) mostly localized at the inner leaflet, which is predicted to induce membrane curvature. Here the authors show that membrane curvature induced by the proximity of anionic phospholipids can induce endocytosis and that cholesterol limits sp...

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Bibliographic Details
Main Authors: Takashi Hirama, Stella M. Lu, Jason G. Kay, Masashi Maekawa, Michael M. Kozlov, Sergio Grinstein, Gregory D. Fairn
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01554-9