SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-κB pathway activation

SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-κB pathway activation

Abstract Background Sterol-regulatory element binding protein 1 (SREBP1), an intracellular cholesterol sensor located in the endoplasmic reticulum, regulates the intracellular cholesterol by the Insig-Srebp-Scap pathway. Over-expression of SREBP1 can cause dyslipidemia. SREBP1 can regulate the metab...

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Bibliographic Details
Main Authors: Yuyan Gao, Xianxiu Nan, Xinjue Shi, Xiaoqin Mu, Binbin Liu, Huifen Zhu, Bingqing Yao, Xinyi Liu, Tianyue Yang, Yiting Hu, Shulin Liu
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Cancer
Subjects:
CRC
Invasion
MMP7
NF-κB
SREBP1
Online Access:http://link.springer.com/article/10.1186/s12885-019-5904-x

Internet

http://link.springer.com/article/10.1186/s12885-019-5904-x

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