Dysregulation of human NEFM and NEFH mRNA stability by ALS-linked miRNAs

Dysregulation of human NEFM and NEFH mRNA stability by ALS-linked miRNAs

Abstract Neurofilaments (NFs) are the most abundant cytoskeletal component of vertebrate myelinated axons. NFs function by determining axonal caliber, promoting axonal growth and forming a 3-dimensional lattice that supports the organization of cytoplasmic organelles. The stoichiometry of NF protein...

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Bibliographic Details
Main Authors: Danae Campos-Melo, Zachary C. E. Hawley, Michael J. Strong
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Molecular Brain
Subjects:
ALS
miRNA
Motor neuron
Neurofilament
NEFM
NEFH
Online Access:http://link.springer.com/article/10.1186/s13041-018-0386-3

Internet

http://link.springer.com/article/10.1186/s13041-018-0386-3

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