Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage

Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage

CaV-channel dependent activation of BK channels is critical for feedback control of both calcium influx and cell excitability. Here we addressed the functional and spatial interaction between BK and CaV1.3 channels, unique CaV1 channels that activate at low voltages. We found that when BK and CaV1.3...

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Bibliographic Details
Main Authors: Oscar Vivas, Claudia M Moreno, Luis F Santana, Bertil Hille
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-06-01
Series:eLife
Subjects:
BK channels
voltage-gated calcium channels
sympathetic neurons
hippocampal neurons
super-resolution microscopy
ground-state depletion
Online Access:https://elifesciences.org/articles/28029

Internet

https://elifesciences.org/articles/28029

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