N-Acetylcysteine Reverses Antiretroviral-Mediated Microglial Activation by Attenuating Autophagy-Lysosomal Dysfunction

N-Acetylcysteine Reverses Antiretroviral-Mediated Microglial Activation by Attenuating Autophagy-Lysosomal Dysfunction

Successful suppression of viral replication by combined antiretroviral therapy (cART) in HIV-1 infected individuals is paradoxically also accompanied by an increased prevalence of HIV-associated neurocognitive disorders (HAND) in these individuals. HAND is characterized by a state of chronic oxidati...

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Bibliographic Details
Main Authors: Ashutosh Tripathi, Annadurai Thangaraj, Ernest T. Chivero, Palsamy Periyasamy, Maria E. Burkovetskaya, Fang Niu, Ming-Lei Guo, Shilpa Buch
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Neurology
Subjects:
combined antiretroviral therapy
N-acetylcysteine
lysosome
autophagy
microglial activation
neuroinflammation
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00840/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2020.00840/full

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