Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction

Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction

The pregnane X receptor (PXR) is a drug/xenobiotic-activated transcription factor of crucial importance for major cytochrome P450 xenobiotic-metabolizing enzymes (CYP) expression and regulation in the liver and the intestine. One of the major target genes regulated by PXR is the cytochrome P450 enzy...

Full description

Bibliographic Details
Main Authors: Jurjen Duintjer Tebbens, Malek Azar, Elfriede Friedmann, Martin Lanzendörfer, Petr Pávek
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
Pregnane X receptor
gene regulation
mathematical models
simulation
Online Access:http://www.mdpi.com/1422-0067/19/6/1785

Internet

http://www.mdpi.com/1422-0067/19/6/1785

Similar Items