Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation

Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation

Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN levels could have promising therapeutic implications for patients carrying GRN mutations. In this study, we explored the ther...

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Bibliographic Details
Main Authors: Shuuichi Miyakawa, Hiroyuki Sakuma, Dnyaneshwar Warude, Satomi Asanuma, Naoto Arimura, Tomoki Yoshihara, Daniel Tavares, Akito Hata, Koh Ida, Yuri Hori, Yuumi Okuzono, Syunsuke Yamamoto, Koichi Iida, Hisao Shimizu, Shinichi Kondo, Shuji Sato
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Neuroscience
Subjects:
sortilin1 (SORT1)
progranulin (PGRN)
granulin (GRN)
monoclonal antibody
frontotemporal dementia
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.586107/full

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https://www.frontiersin.org/articles/10.3389/fnins.2020.586107/full

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