Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards

Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards

Human pluripotent stem cell derived therapies can have serious safety risks. Here the authors design two drug inducible genetic safeguards to deplete undifferentiated hPSCs and hPSC-derived cell types.

Bibliographic Details
Main Authors: Renata M. Martin, Jonas L. Fowler, M. Kyle Cromer, Benjamin J. Lesch, Ezequiel Ponce, Nobuko Uchida, Toshinobu Nishimura, Matthew H. Porteus, Kyle M. Loh
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16455-7

Internet

https://doi.org/10.1038/s41467-020-16455-7

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