MDM2-p53 Interactions in Human Hepatocellular Carcinoma: What Is the Role of Nutlins and New Therapeutic Options?

Human hepatocellular carcinoma (HCC) is the fifth most common cancer and is associated with poor prognosis worldwide. The molecular mechanisms underlying the pathogenesis of HCC have been an area of continuing interest, and recent studies using next generation sequencing (NGS) have revealed much reg...

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Bibliographic Details
Main Author: Samy A. Azer
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Journal of Clinical Medicine
Subjects:
p53
Online Access:http://www.mdpi.com/2077-0383/7/4/64