Development and characterization of naive single-type tumor antigen-specific CD8+ T lymphocytes from murine pluripotent stem cells

Development and characterization of naive single-type tumor antigen-specific CD8+ T lymphocytes from murine pluripotent stem cells

Optimal approaches to differentiate tumor antigen-specific cytotoxic T lymphocytes (CTLs) from pluripotent stem cells (PSCs) remain elusive. In the current study, we showed that combination of in vitro priming through Notch ligands and in vivo development facilitated the generation of tumor Ag-speci...

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Bibliographic Details
Main Authors: Fengyang Lei, Mohammad Haque, Praneet Sandhu, Swetha Ravi, Jianyong Song, Bing Ni, Songguo Zheng, Deyu Fang, Hongyan Jia, Jin-Ming Yang, Jianxun Song
Format: Article
Language:English
Published: Taylor & Francis Group 2017-07-01
Series:OncoImmunology
Subjects:
cytotoxic t lymphocytes
immunotherapy
melanoma, mouse
pluripotent stem cells
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1334027

Internet

http://dx.doi.org/10.1080/2162402X.2017.1334027

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