Reprogramming of Lipid Metabolism as a New Driving Force Behind Tauroursodeoxycholic Acid-Induced Neural Stem Cell Proliferation

Reprogramming of Lipid Metabolism as a New Driving Force Behind Tauroursodeoxycholic Acid-Induced Neural Stem Cell Proliferation

Recent evidence suggests that neural stem cell (NSC) fate is highly dependent on mitochondrial bioenergetics. Tauroursodeoxycholic acid (TUDCA), an endogenous neuroprotective bile acid and a metabolic regulator, stimulates NSC proliferation and enhances adult NSC pool in vitro and in vivo. In this s...

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Bibliographic Details
Main Authors: Marta B. Fernandes, Márcia Costa, Maria Filipe Ribeiro, Sónia Siquenique, Sónia Sá Santos, Joana Martins, Ana V. Coelho, Margarida F. B. Silva, Cecília M. P. Rodrigues, Susana Solá
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
metabolism
mitochondria
neural stem cells
proliferation
tauroursodeoxycholic acid
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00335/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00335/full

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