Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

The development of pancreatic cancer requires the acquisition of oncogenic KRas mutations and upregulation of growth factor signaling, but the relationship between these is not well established. Here, we show that mutant KRas alters mitochondrial metabolism in pancreatic acinar cells, resulting in i...

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Bibliographic Details
Main Authors: Geou-Yarh Liou, Heike Döppler, Kathleen E. DelGiorno, Lizhi Zhang, Michael Leitges, Howard C. Crawford, Michael P. Murphy, Peter Storz
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Subjects:
pancreatic cancer
PanIN
Kras
oxidative stress
mitochondria
growth factor signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716301322

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http://www.sciencedirect.com/science/article/pii/S2211124716301322

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