The CDK Pef1 and protein phosphatase 4 oppose each other for regulating cohesin binding to fission yeast chromosomes

The CDK Pef1 and protein phosphatase 4 oppose each other for regulating cohesin binding to fission yeast chromosomes

Cohesin has essential roles in chromosome structure, segregation and repair. Cohesin binding to chromosomes is catalyzed by the cohesin loader, Mis4 in fission yeast. How cells fine tune cohesin deposition is largely unknown. Here, we provide evidence that Mis4 activity is regulated by phosphorylati...

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Bibliographic Details
Main Authors: Adrien Birot, Marta Tormos-Pérez, Sabine Vaur, Amélie Feytout, Julien Jaegy, Dácil Alonso Gil, Stéphanie Vazquez, Karl Ekwall, Jean-Paul Javerzat
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
cohesin
Phosphatase
CDK
cohesion
loop extrusion
S. pombe
Online Access:https://elifesciences.org/articles/50556

Internet

https://elifesciences.org/articles/50556

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