The Opposite Effect of c-Jun Transcription Factor on Apolipoprotein E Gene Regulation in Hepatocytes and Macrophages

The Opposite Effect of c-Jun Transcription Factor on Apolipoprotein E Gene Regulation in Hepatocytes and Macrophages

Apolipoprotein E (apoE) is mainly secreted by hepatocytes and incorporated into most plasma lipoproteins. Macrophages, which accumulate cholesterol and are critical for the development of the atherosclerotic plaque, are also an important, albeit smaller, apoE source. Distal regulatory elements contr...

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Bibliographic Details
Main Authors: Violeta G. Trusca, Elena V. Fuior, Dimitris Kardassis, Maya Simionescu, Anca V. Gafencu
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
apoE
apolipoproteins
c-Jun
AP-1
promoter
enhancer
ME.2
hepatocytes
macrophages
Online Access:https://www.mdpi.com/1422-0067/20/6/1471

Internet

https://www.mdpi.com/1422-0067/20/6/1471

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