Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

Controversy exists over the function of plasma membrane versus intracellular vesicular LAT in T-cell receptor signaling. Here the authors use high resolution imaging of the temporal dynamics of LAT involvement to show that both sources of LAT are required, but at distinct stages.

Bibliographic Details
Main Authors: Lakshmi Balagopalan, Jason Yi, Tiffany Nguyen, Katherine M. McIntire, Adam S. Harned, Kedar Narayan, Lawrence E. Samelson
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04419-x
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spelling doaj-1b98fb09066a499aa682b8e55ae6a06f2021-05-11T10:32:53ZengNature Publishing GroupNature Communications2041-17232018-05-019111710.1038/s41467-018-04419-xPlasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activationLakshmi Balagopalan0Jason Yi1Tiffany Nguyen2Katherine M. McIntire3Adam S. Harned4Kedar Narayan5Lawrence E. Samelson6Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of HealthCenter for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of HealthCenter for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of HealthControversy exists over the function of plasma membrane versus intracellular vesicular LAT in T-cell receptor signaling. Here the authors use high resolution imaging of the temporal dynamics of LAT involvement to show that both sources of LAT are required, but at distinct stages.https://doi.org/10.1038/s41467-018-04419-x
collection DOAJ
language English
format Article
sources DOAJ
author Lakshmi Balagopalan
Jason Yi
Tiffany Nguyen
Katherine M. McIntire
Adam S. Harned
Kedar Narayan
Lawrence E. Samelson
spellingShingle Lakshmi Balagopalan
Jason Yi
Tiffany Nguyen
Katherine M. McIntire
Adam S. Harned
Kedar Narayan
Lawrence E. Samelson
Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation
Nature Communications
author_facet Lakshmi Balagopalan
Jason Yi
Tiffany Nguyen
Katherine M. McIntire
Adam S. Harned
Kedar Narayan
Lawrence E. Samelson
author_sort Lakshmi Balagopalan
title Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation
title_short Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation
title_full Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation
title_fullStr Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation
title_full_unstemmed Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation
title_sort plasma membrane lat activation precedes vesicular recruitment defining two phases of early t-cell activation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-05-01
description Controversy exists over the function of plasma membrane versus intracellular vesicular LAT in T-cell receptor signaling. Here the authors use high resolution imaging of the temporal dynamics of LAT involvement to show that both sources of LAT are required, but at distinct stages.
url https://doi.org/10.1038/s41467-018-04419-x
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AT tiffanynguyen plasmamembranelatactivationprecedesvesicularrecruitmentdefiningtwophasesofearlytcellactivation
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AT adamsharned plasmamembranelatactivationprecedesvesicularrecruitmentdefiningtwophasesofearlytcellactivation
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