Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

Controversy exists over the function of plasma membrane versus intracellular vesicular LAT in T-cell receptor signaling. Here the authors use high resolution imaging of the temporal dynamics of LAT involvement to show that both sources of LAT are required, but at distinct stages.

Bibliographic Details
Main Authors: Lakshmi Balagopalan, Jason Yi, Tiffany Nguyen, Katherine M. McIntire, Adam S. Harned, Kedar Narayan, Lawrence E. Samelson
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04419-x

Internet

https://doi.org/10.1038/s41467-018-04419-x

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