Subcellular targeting and dynamic regulation of PTEN: Implications for neuronal cells and neurological disorders

Subcellular targeting and dynamic regulation of PTEN: Implications for neuronal cells and neurological disorders

PTEN is a lipid and protein phosphatase that regulates a diverse range of cellular mechanisms. PTEN is mainly present in the cytosol and transiently associates with the plasma membrane to dephosphorylate PI(3,4,5)P3, thereby antagonizing the PI3-Kinase signaling pathway. Recently, PTEN has been show...

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Bibliographic Details
Main Authors: Patricia eKreis, George eLeondaritis, Ivo eLieberam, Britta Johanna Eickholt
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Membranes
PTEN Phosphohydrolase
Synaptic Transmission
Neuronal morphology
PI3K/AKT/mTOR
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00023/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00023/full

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