Inhibition of the oligosaccharyl transferase in Caenorhabditis elegans that compromises ER proteostasis suppresses p38-dependent protection against pathogenic bacteria.

Inhibition of the oligosaccharyl transferase in Caenorhabditis elegans that compromises ER proteostasis suppresses p38-dependent protection against pathogenic bacteria.

The oligosaccharyl transferase (OST) protein complex mediates the N-linked glycosylation of substrate proteins in the endoplasmic reticulum (ER), which regulates stability, activity, and localization of its substrates. Although many OST substrate proteins have been identified, the physiological role...

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Main Authors: Dae-Eun Jeong, Yujin Lee, Seokjin Ham, Dongyeop Lee, Sujeong Kwon, Hae-Eun H Park, Sun-Young Hwang, Joo-Yeon Yoo, Tae-Young Roh, Seung-Jae V Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-03-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008617

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https://doi.org/10.1371/journal.pgen.1008617

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