Intestinal Barrier Breakdown and Mucosal Microbiota Disturbance in Neuromyelitis Optical Spectrum Disorders

Intestinal Barrier Breakdown and Mucosal Microbiota Disturbance in Neuromyelitis Optical Spectrum Disorders

Background and PurposeThe mechanism underlying the pathology of neuromyelitis optica spectrum disorders (NMOSD) remains unclear even though antibodies to the water channel protein aquaporin-4 (AQP4) on astrocytes play important roles. Our previous study showed that dysbiosis occurred in the fecal mi...

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Bibliographic Details
Main Authors: Chunping Cui, Sha Tan, Li Tao, Junli Gong, Yanyu Chang, Yuge Wang, Ping Fan, Dan He, Yiwen Ruan, Wei Qiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
neuromyelitis optica spectrum disorders
tight junction
intestinal barrier
mucosa microbiota
intestinal inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02101/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.02101/full

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