Behavioral flexibility is associated with changes in structure and function distributed across a frontal cortical network in macaques.

Behavioral flexibility is associated with changes in structure and function distributed across a frontal cortical network in macaques.

One of the most influential accounts of central orbitofrontal cortex-that it mediates behavioral flexibility-has been challenged by the finding that discrimination reversal in macaques, the classic test of behavioral flexibility, is unaffected when lesions are made by excitotoxin injection rather th...

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Bibliographic Details
Main Authors: Jérôme Sallet, MaryAnn P Noonan, Adam Thomas, Jill X O'Reilly, Jesper Anderson, Georgios K Papageorgiou, Franz X Neubert, Bashir Ahmed, Jackson Smith, Andrew H Bell, Mark J Buckley, Léa Roumazeilles, Steven Cuell, Mark E Walton, Kristine Krug, Rogier B Mars, Matthew F S Rushworth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-05-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000605

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https://doi.org/10.1371/journal.pbio.3000605

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