Genome‐wide off‐rates reveal how DNA binding dynamics shape transcription factor function

Abstract Protein–DNA interactions are dynamic, and these dynamics are an important aspect of chromatin‐associated processes such as transcription or replication. Due to a lack of methods to study on‐ and off‐rates across entire genomes, protein–DNA interaction dynamics have not been studied extensiv...

Full description

Bibliographic Details
Main Authors: Wim J de Jonge, Mariël Brok, Philip Lijnzaad, Patrick Kemmeren, Frank CP Holstege
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.15252/msb.20209885