Protein Expression Correlates Linearly with mRNA Dose over Up to Five Orders of Magnitude In Vitro and In Vivo

Protein Expression Correlates Linearly with mRNA Dose over Up to Five Orders of Magnitude In Vitro and In Vivo

Messenger RNA is rapidly gaining significance as a therapeutic modality. Here, we address the dependence of dose–response functions on the type of delivery vehicle, cell line, and incubation time. Knowledge of these characteristics is crucial for the application of mRNA. As delivery vehicles, a lipi...

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Bibliographic Details
Main Authors: Alexander H. van Asbeck, Jürgen Dieker, Rik Oude Egberink, Lennard van den Berg, Johan van der Vlag, Roland Brock
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biomedicines
Subjects:
messenger RNA
dose response function
nanomedicine
drug delivery
Online Access:https://www.mdpi.com/2227-9059/9/5/511

Internet

https://www.mdpi.com/2227-9059/9/5/511

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