Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells

Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells

Immunotherapies that target CD1d-restricted invariant NKT (iNKT) cells can prevent tumor growth in murine models but trials in humans have shown limited clinical efficacy. Here, we show that iNKT cells are depleted from blood and bronchial lavage samples from patients with non-small cell lung cancer...

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Bibliographic Details
Main Authors: Éilis Dockry, Seónadh O'Leary, Laura E. Gleeson, Judith Lyons, Joseph Keane, Steven G. Gray, Derek G. Doherty
Format: Article
Language:English
Published: Taylor & Francis Group 2018-06-01
Series:OncoImmunology
Subjects:
cd1d
cytolytic
epigenetic
degranulation
invariant nkt cells
lung cancer
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1428156

Internet

http://dx.doi.org/10.1080/2162402X.2018.1428156

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