IL-17RA signaling reduces inflammation and mortality during Trypanosoma cruzi infection by recruiting suppressive IL-10-producing neutrophils.

IL-17RA signaling reduces inflammation and mortality during Trypanosoma cruzi infection by recruiting suppressive IL-10-producing neutrophils.

Members of the IL-17 cytokine family play an important role in protection against pathogens through the induction of different effector mechanisms. We determined that IL-17A, IL-17E and IL-17F are produced during the acute phase of T. cruzi infection. Using IL-17RA knockout (KO) mice, we demonstrate...

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Bibliographic Details
Main Authors: Jimena Tosello Boari, María Carolina Amezcua Vesely, Daniela Andrea Bermejo, Maria Cecilia Ramello, Carolina Lucía Montes, Hugo Cejas, Adriana Gruppi, Eva Virginia Acosta Rodríguez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3343119?pdf=render

Internet

http://europepmc.org/articles/PMC3343119?pdf=render

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