Conversion of Reactive Astrocytes to Induced Neurons Enhances Neuronal Repair and Functional Recovery After Ischemic Stroke

Conversion of Reactive Astrocytes to Induced Neurons Enhances Neuronal Repair and Functional Recovery After Ischemic Stroke

The master neuronal transcription factor NeuroD1 can directly reprogram astrocytes into induced neurons (iNeurons) after stroke. Using viral vectors to drive ectopic ND1 expression in gliotic astrocytes after brain injury presents an autologous form of cell therapy for neurodegenerative disease. Cul...

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Bibliographic Details
Main Authors: Michael Qize Jiang, Shan Ping Yu, Zheng Zachory Wei, Weiwei Zhong, Wenyuan Cao, Xiaohuan Gu, Anika Wu, Myles Randolph McCrary, Ken Berglund, Ling Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
ischemic stroke
direct reprogramming
induced neuron
glial scar
functional recovery
post-stroke depression
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.612856/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.612856/full

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