The Importance of Poly(ethylene glycol) and Lipid Structure in Targeted Gene Delivery to Lymph Nodes by Lipid Nanoparticles

The Importance of Poly(ethylene glycol) and Lipid Structure in Targeted Gene Delivery to Lymph Nodes by Lipid Nanoparticles

Targeted delivery of nucleic acids to lymph nodes is critical for the development of effective vaccines and immunotherapies. However, it remains challenging to achieve selective lymph node delivery. Current gene delivery systems target mainly to the liver and typically exhibit off-target transfectio...

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Bibliographic Details
Main Authors: Danijela Zukancic, Estelle J. A. Suys, Emily H. Pilkington, Azizah Algarni, Hareth Al-Wassiti, Nghia P. Truong
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceutics
Subjects:
gene delivery
plasmid DNA (pDNA)
transfection
lymph node targeting
PEGylation
lipid nanoparticles
Online Access:https://www.mdpi.com/1999-4923/12/11/1068

Internet

https://www.mdpi.com/1999-4923/12/11/1068

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