NSC348884 cytotoxicity is not mediated by inhibition of nucleophosmin oligomerization

NSC348884 cytotoxicity is not mediated by inhibition of nucleophosmin oligomerization

Abstract Nucleophosmin (NPM) mutations causing its export from the nucleoli to the cytoplasm are frequent in acute myeloid leukemia (AML). Due to heterooligomerization of wild type NPM with the AML-related mutant, the wild-type becomes misplaced from the nucleoli and its functions are significantly...

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Main Authors: Markéta Šašinková, Petr Heřman, Aleš Holoubek, Dita Strachotová, Petra Otevřelová, Dana Grebeňová, Kateřina Kuželová, Barbora Brodská
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-80224-1

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