DNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6

DNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6

Abstract Background The production of reactive oxygen species (ROS) during pneumococcal meningitis (PM) leads to severe DNA damage in the neurons and is the major cause of cell death during infection. Hence, the use of antioxidants as adjuvant therapy has been investigated. Previous studies have dem...

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Bibliographic Details
Main Authors: Leonam G. Coutinho, Ana Helena Sales de Oliveira, Matthias Witwer, Stephen L. Leib, Lucymara F. Agnez-Lima
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Journal of Neuroinflammation
Subjects:
APE1
Pneumococcal meningitis
Vitamin B6
Cortex
Hippocampus
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s12974-017-1020-5

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http://link.springer.com/article/10.1186/s12974-017-1020-5

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