Stimulation of α7 Nicotinic Acetylcholine Receptor by Nicotine Suppresses Decidual M1 Macrophage Polarization Against Inflammation in Lipopolysaccharide-Induced Preeclampsia-Like Mouse Model

Stimulation of α7 Nicotinic Acetylcholine Receptor by Nicotine Suppresses Decidual M1 Macrophage Polarization Against Inflammation in Lipopolysaccharide-Induced Preeclampsia-Like Mouse Model

Changes in decidual macrophage polarization affect local inflammatory microenvironment and lead to adverse pregnancy outcomes. However, the regulatory mechanism of macrophage polarization in preeclampsia (PE) remains unclear. In this study, we found that α7nAChR expression was significantly down-reg...

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Bibliographic Details
Main Authors: Xinjia Han, Wei Li, Ping Li, Zheng Zheng, Baohua Lin, Bei Zhou, Kaimin Guo, Ping He, Jinying Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
α7nAChR
nicotine
decidual macrophage
placenta
preeclampsia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.642071/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.642071/full

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