Identification of STRBP as a Novel JAK2 Fusion Partner Gene in a Young Adult With Philadelphia Chromosome-Like B-Lymphoblastic Leukemia

Identification of STRBP as a Novel JAK2 Fusion Partner Gene in a Young Adult With Philadelphia Chromosome-Like B-Lymphoblastic Leukemia

Philadelphia chromosome-like B-lymphoblastic leukemia (Ph-like ALL) describes a group of genetically heterogeneous, Ph-negative entities with high relapse rates and poor prognoses. A Janus-kinase-2 (JAK2) rearrangement has been reported in approximately 7% of Ph-like ALL patients whose therapeutic r...

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Bibliographic Details
Main Authors: Xin-Yue Zhang, Hai-Ping Dai, Zheng Li, Jia Yin, Xing-Ping Lang, Chun-Xiao Yang, Sheng Xiao, Ming-Qing Zhu, Dan-Dan Liu, Hong Liu, Hong-Jie Shen, De-Pei Wu, Xiao-Wen Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
fusion gene
STRBP-JAK2
Ph-like
chimeric antigen receptor
B-lymphoblastic leukemia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.611467/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.611467/full

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