Multicolour fluorescence-detection size-exclusion chromatography for structural genomics of membrane multiprotein complexes.

Many interesting and important membrane proteins are hetero-oligomeric. However, besides naturally abundant examples, the structures of relatively few such complexes are known. Partly, this is due to difficulties in expression, stoichiometric assembly, and in the evaluation of their stability prior...

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Bibliographic Details
Main Authors: David Parcej, Renate Guntrum, Sabine Schmidt, Andreas Hinz, Robert Tampé
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3692423?pdf=render