Redox signaling during hypoxia in mammalian cells

Hypoxia triggers a wide range of protective responses in mammalian cells, which are mediated through transcriptional and post-translational mechanisms. Redox signaling in cells by reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) occurs through the reversible oxidation of cysteine thiol...

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Bibliographic Details
Main Authors: Kimberly A. Smith, Gregory B. Waypa, Paul T. Schumacker
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717302355