Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism

Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism

Abstract Background Radiotherapy has been used increasingly to treat primary hepatocellular carcinoma. Clinically, the main cause of radiotherapy failure is cellular radioresistance, conferred via glycolytic metabolism. Our previous study demonstrated that Girdin is upregulated in primary hepatocell...

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Bibliographic Details
Main Authors: Li Yu, Yifan Sun, Jingjing Li, Yan Wang, Yuxing Zhu, Yong Shi, Xiaojun Fan, Jianda Zhou, Ying Bao, Jie Xiao, Ke Cao, Peiguo Cao
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Girdin
Primary hepatocellular carcinoma
Glycolysis
Radio-sensitivity
Online Access:http://link.springer.com/article/10.1186/s13046-017-0580-7

Internet

http://link.springer.com/article/10.1186/s13046-017-0580-7

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