Chimeric RNA-binding protein-based killing switch targeting hepatocellular carcinoma cells

Chimeric RNA-binding protein-based killing switch targeting hepatocellular carcinoma cells

Cancer cell-specific killing switches are synthetic circuits developed as an intelligent weapon to specifically eliminate malignant cells. RNA-delivered synthetic circuits provide safer means to control oncolytic functions, in which proteolysis-responding capsid-cNOT7 is developed to enable logic co...

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Bibliographic Details
Main Authors: Jiong Yang, Shigang Ding
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
synthetic circuit
modRNA delivery
RNA-binding protein
protease
HCC
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121002067

Internet

http://www.sciencedirect.com/science/article/pii/S2162253121002067

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