Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines

Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines

An efficient enantioselective NMR analysis of atropisomeric quinolines in the promotion of chiral phosphoric acid is described, in which a variety of racemic 4-aryl quinolines were well-recognized with up to 0.17 ppm ΔΔδ value. Additionally, the optical purities of different nonracemic substrates co...

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Bibliographic Details
Main Authors: Junlin Wan, Jun Jiang, Juan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Chemistry
Subjects:
chiral recognition
1H NMR analysis
quinolines
chiral phosphoric acid
chiral shift reagents
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.672704/full
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spelling doaj-1aec09e5a18748c78ab29be0ef279ec92021-06-10T04:41:38ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-06-01910.3389/fchem.2021.672704672704Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric QuinolinesJunlin WanJun JiangJuan LiAn efficient enantioselective NMR analysis of atropisomeric quinolines in the promotion of chiral phosphoric acid is described, in which a variety of racemic 4-aryl quinolines were well-recognized with up to 0.17 ppm ΔΔδ value. Additionally, the optical purities of different nonracemic substrates could be evaluated fast via NMR analysis with high accuracy.https://www.frontiersin.org/articles/10.3389/fchem.2021.672704/fullchiral recognition1H NMR analysisquinolineschiral phosphoric acidchiral shift reagents
collection DOAJ
language English
format Article
sources DOAJ
author Junlin Wan
Jun Jiang
Juan Li
spellingShingle Junlin Wan
Jun Jiang
Juan Li
Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines
Frontiers in Chemistry
chiral recognition
1H NMR analysis
quinolines
chiral phosphoric acid
chiral shift reagents
author_facet Junlin Wan
Jun Jiang
Juan Li
author_sort Junlin Wan
title Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines
title_short Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines
title_full Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines
title_fullStr Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines
title_full_unstemmed Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines
title_sort chiral phosphoric acid promoted chiral 1h nmr analysis of atropisomeric quinolines
publisher Frontiers Media S.A.
series Frontiers in Chemistry
issn 2296-2646
publishDate 2021-06-01
description An efficient enantioselective NMR analysis of atropisomeric quinolines in the promotion of chiral phosphoric acid is described, in which a variety of racemic 4-aryl quinolines were well-recognized with up to 0.17 ppm ΔΔδ value. Additionally, the optical purities of different nonracemic substrates could be evaluated fast via NMR analysis with high accuracy.
topic chiral recognition
1H NMR analysis
quinolines
chiral phosphoric acid
chiral shift reagents
url https://www.frontiersin.org/articles/10.3389/fchem.2021.672704/full
work_keys_str_mv AT junlinwan chiralphosphoricacidpromotedchiral1hnmranalysisofatropisomericquinolines
AT junjiang chiralphosphoricacidpromotedchiral1hnmranalysisofatropisomericquinolines
AT juanli chiralphosphoricacidpromotedchiral1hnmranalysisofatropisomericquinolines
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