Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells

Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells

Abstract Ouabain (OUA) is a cardiac glycoside that binds to Na+,K+-ATPase (NKA), a conserved membrane protein that controls cell transmembrane ionic concentrations and requires ATP hydrolysis. At nM concentrations, OUA activates signaling pathways that are not related to its typical inhibitory effec...

Full description

Bibliographic Details
Main Authors: Paula F. Kinoshita, Lidia M. Yshii, Ana Maria M. Orellana, Amanda G. Paixão, Andrea R. Vasconcelos, Larissa de Sá Lima, Elisa M. Kawamoto, Cristoforo Scavone
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05075-9

Internet

https://doi.org/10.1038/s41598-017-05075-9

Similar Items