Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

Hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS) are rare motor neuron diseases, which affect mostly the upper motor neurons (UMNs) in patients. The UMNs display early vulnerability and progressive degeneration, while other cortical neurons mostly remain functional. Identifica...

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Bibliographic Details
Main Authors:  Oge Gozutok, Benjamin Ryan Helmold, P. Hande Ozdinler
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Brain Sciences
Subjects:
upper motor neurons
protein landscape
interaction domain
upstream regulator
lipid homeostasis
growth factors
Online Access:https://www.mdpi.com/2076-3425/11/5/578

Internet

https://www.mdpi.com/2076-3425/11/5/578

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