Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness

Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness

Abstract Background We have previously shown that the deletion of the superoxide scavenger, CuZn superoxide dismutase, in mice (Sod1−/− mice) results in increased oxidative stress and an accelerated loss of skeletal muscle mass and force that mirror the changes seen in old control mice. The goal of...

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Bibliographic Details
Main Authors: Rizwan Qaisar, Shylesh Bhaskaran, Pavithra Premkumar, Rojina Ranjit, Kavithalakshmi Satara Natarajan, Bumsoo Ahn, Kaitlyn Riddle, Dennis R. Claflin, Arlan Richardson, Susan V. Brooks, Holly Van Remmen
Format: Article
Language:English
Published: Wiley 2018-10-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Excitation contraction coupling
Skeletal muscle
SERCA pump
Sarcolipin
Sod1
Sarcopenia
Online Access:https://doi.org/10.1002/jcsm.12339

Internet

https://doi.org/10.1002/jcsm.12339

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