DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization

DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization

Mice and human patients with impaired vitamin D receptor (VDR) signaling have normal developmental hair growth but display aberrant post-morphogenic hair cycle progression associated with alopecia. In addition, VDR–/– mice exhibit impaired cutaneous wound healing. We undertook experiments to determi...

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Bibliographic Details
Main Authors: Hengguang Zhao, Sandra Rieger, Koichiro Abe, Martin Hewison, Thomas S. Lisse
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:International Journal of Molecular Sciences
Subjects:
wound repair
VDR
mTOR
DDIT4
stress
hair follicle
stem cells
Online Access:http://www.mdpi.com/1422-0067/17/12/1984

Internet

http://www.mdpi.com/1422-0067/17/12/1984

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